Induced Pluripotent Stem Cells (iPSCs)

CTNNB1 DNA VariantCTNNB1 Protein VariantSourceNotes
211dupTSer71Phefs*11SFARIRequest here
514_518dupGCAGTMet174Glnfs*37SFARIRequest here
1962T>ATyr654*SFARIRequest here
1469_1488delGly490Alafs*33SFARIRequest here
283C>TArg95*SFARIRequest here
981_982delAAMet328Glufs*24SFARIRequest here
1354_1357delCTTCLeu452Glyfs*19SFARIRequest here

Animal Models

Ctnnb1⁺
Species: Mouse
Background Strain: Hybrid mix of background strains C57B6/J; 129/SvJ; FVB CTNNB1
Genetic Modifications: Deletion of exons 2-6 resulting in loss of functional β-catenin protein
Source: M. Jacob, Tufts University, Boston, MA
References: PMID 39103699
To request, please email michele.jacob@tufts.edu

C3.Cg-Ctnnb1ᴮᶠᶜ/H
Species: Mouse
Background Strain: (C3H/HeNCrl x BALB/cAnNCrl)F1
Genetic Modifications: ENU mutagenesis induced a C to A transversion that results in the amino acid substitution of lysine for threonine at position 653 (T653K)
Source: UKRI-MRC Harwell Institute, United Kingdom
References: PMID 24614104
To request, please visit https://archive.har.mrc.ac.uk/stock?id=000065

Biorepository

CTNNB1 Connect and Cure has partnered with COMBINEDBrain to establish a biorepository. 

View sample catalog here (scroll down to see available CTNNB1 patient and control samples)

Request samples here