At the heart of our mission is funding research that ultimately leads to a cure for CTNNB1 Syndrome. Guided by the Scientific Advisory Board, donations are distributed to researchers who are working as quickly and efficiently as possible to understand the CTNNB1 gene, the effects of gene mutations or deletions, and move us closer to clinical trials that are necessary for treating CTNNB1 Syndrome.

The Path to Treatment

The path to treatment isn’t easy, but remarkable progress has been made thanks to a team of dedicated researchers and our supporters.

Establish patient registry
COMPLETE!
Begin natural history study
COMPLETE!
CTNNB1 mouse model
COMPLETE!
CTNNB1 cell models
COMPLETE!
CTNNB1 patient-derived cell models
COMPLETE!
Identify potential targets
COMPLETE!
Establish biobanks
COMPLETE!
Understand genotype-phenotype correlation across all mutation types
IN PROGRESS
Identify biomarkers
IN PROGRESS
Register patients
IN PROGRESS
Identify potential small molecule treatment
COMPLETE!
Explore and support other treatment approaches
IN PROGRESS
Optimize small molecule
IN PROGRESS
Collect biobank samples
IN PROGRESS
Begin clinical trials for small molecule treatment (UPCOMING)

In collaboration with Wendy Chung, MD, PhD, at Boston Children’s Hospital and Michele Jacob, PhD, at Tufts University School of Medicine, we’ve prioritized and funded research that’s leading the way when it comes to solving the unknowns of CTNNB1 Syndrome.

Our Natural History Studies are vital for future clinical trials. To date, over 250 families have registered!

Our research conferences are an opportunity for families and researchers to get together and hear about progress from recent CTNNB1 studies. Learn more about this year’s conference and catch up on what you missed in previous years’ conferences.

While there is significant research on the CTNNB1 gene in relation to cancer, there is relatively little known about the de novo genetic mutation that causes CTNNB1 Syndrome. Browse our list of related medical studies and scientific articles.