Patient-Derived Induced Pluripotent Stem Cells (iPSCs)
| CTNNB1 DNA Variant | CTNNB1 Protein Variant | Source | Notes |
|---|---|---|---|
| 211dupT | Ser71Phefs*11 | SFARI | Request here |
| 514_518dupGCAGT | Met174Glnfs*37 | SFARI | Request here |
| 1962T>A | Tyr654* | SFARI | Request here |
| 1469_1488del | Gly490Alafs*33 | SFARI | Request here |
| 283C>T | Arg95* | SFARI | Request here |
| 981_982delAA | Met328Glufs*24 | SFARI | Request here |
| 1354_1357delCTTC | Leu452Glyfs*19 | SFARI | Request here |
| 1987_1990delTCTG | Ser663Argfs*15 | SFARI | Request here |
| NA | Tyr333* | SFARI | Coming Soon |
SFARI also has familial controls available for request. See the full updated list of available iPSCs here.
Animal Models
Ctnnb1⁺⁄⁻
Species: Mouse
Background Strain: Hybrid mix of background strains C57B6/J; 129/SvJ; FVB CTNNB1
Genetic Modifications: Deletion of exons 2-6 resulting in loss of functional β-catenin protein
Source: M. Jacob, Tufts University, Boston, MA
References: PMID 39103699
To request, please email michele.jacob@tufts.edu.
C3.Cg-Ctnnb1ᴮᶠᶜ/H
Species: Mouse
Background Strain: (C3H/HeNCrl x BALB/cAnNCrl)F1
Genetic Modifications: ENU mutagenesis induced a C to A transversion that results in the amino acid substitution of lysine for threonine at position 653 (T653K)
Source: UKRI – Mary Lyon Centre at MRC Harwell, United Kingdom
References: PMID 24614104
To request, please visit https://archive.har.mrc.ac.uk/stock?id=000065.
C57BL/6J-Ctnnb1em1H/H
Species: Mouse
Background Strain: C57BL/6J
Genetic Modifications: CRISPR-targeting introduced the substitution of histidine with a stop codon at position 720 (H720X).
Source: UKRI – Mary Lyon Centre at MRC Harwell, United Kingdom
To request, please visit https://archive.har.mrc.ac.uk/stock?id=009189.